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Related Experiment Video

Updated: Dec 10, 2025

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

A corneal ring ulcer.

Khaled Alhajraf¹, Shawn R Lin², Deborah S Jacobs¹

¹Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

American Journal of Ophthalmology Case Reports

|September 3, 2020

Summary

This summary is machine-generated.

A challenging case of a ring-shaped corneal ulcer following ranibizumab injection is presented. This condition can mimic infectious keratitis, highlighting the importance of considering neurotrophic causes.

Keywords:

Acanthamoeba keratitis Cenegermin Cornea Neurotrophic ulcer Ring ulcer

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Area of Science:

Ophthalmology
Corneal Diseases

Background:

Diabetic macular edema is a common complication of diabetes.
Intravitreal ranibizumab injections are a standard treatment for diabetic macular edema.
Corneal complications can arise after intravitreal injections.

Observation:

A 52-year-old woman developed a ring-shaped corneal ulcer with severe pain and vision loss post-intravitreal ranibizumab injection.
Initial treatments with topical antibiotics and a contact lens were ineffective.

Findings:

The corneal ulcer presented a diagnostic challenge, initially suspected to be infectious keratitis.
Despite antimicrobial treatment, the ulcer persisted, suggesting an alternative etiology.

Implications:

Neurotrophic corneal ulcers can mimic infectious keratitis, necessitating a broad differential diagnosis.
Consideration of neurotrophic disease is crucial for patients with risk factors and non-responsive corneal ulcers.
Prompt recognition and appropriate management of neurotrophic ulcers are vital to prevent vision loss.