Molecular diversity in pathogenic variants of vibrio parahaemolyticus in Peru

Junior Caro-Castro1,2, Orson Mestanza1, Willi Quino1

  • 1Instituto Nacional de Salud, Lima, Perú.

Insights

Vibrio parahaemolyticus pathogenic variants in Peru were analyzed between 1995-2017. The ST3 genotype, linked to past outbreaks, was most common, posing a public health risk from seafood.

Area of Science:

  • Microbiology
  • Genomics
  • Public Health

Background:

  • Vibrio parahaemolyticus is a significant cause of seafood-borne gastroenteritis globally.
  • Understanding the genetic diversity and virulence factors of V. parahaemolyticus is crucial for public health surveillance.

Purpose of the Study:

  • To characterize the genetic diversity and identify virulence genes of Vibrio parahaemolyticus strains in Peru from 1995 to 2017.
  • To assess the public health implications of identified V. parahaemolyticus genotypes.

Main Methods:

  • Analysis of 102 Peruvian V. parahaemolyticus genomes using multilocus sequence typing.
  • Detection of virulence genes, including the pathogenicity island VpaI-7, tdh, and trh, using BLASTn.

Main Results:

  • Fifteen distinct sequence types (STs) were identified among the analyzed strains.
  • ST3, associated with a pandemic clone and past outbreaks, was the most prevalent (52%).
  • High prevalence of the VpaI-7 (87.3%) and tdh (94.1%) genes was observed, while the trh gene was less common (5.9%).

Conclusions:

  • The ST3 genotype was the predominant V. parahaemolyticus variant in Peru during the study period.
  • The presence of other pathogenic genotypes highlights a persistent public health risk associated with seafood consumption in the region.

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