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Related Experiment Video

Updated: Dec 10, 2025

State of the Art Cranial Ultrasound Imaging in Neonates
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State of the Art Cranial Ultrasound Imaging in Neonates

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Quantitative Evaluation of Neonatal Brain Elasticity Using Shear Wave Elastography.

Enrique Garcés Iñigo1, Roberto Llorens Salvador2, Raquel Escrig3

  • 1Department of Radiology, Hospital de Sagunto, Valencia, Spain.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|September 3, 2020
PubMed
Summary

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This study shows that 2-dimensional brain ultrasound shear wave elastography (SWE) is feasible for measuring neonatal brain elasticity. The elasticity of the thalamus and corona radiata differs significantly in healthy term infants.

Area of Science:

  • Neuroimaging
  • Biophysics
  • Pediatric Imaging

Background:

  • Establishing normative elasticity values for neonatal brain structures is crucial for understanding development and detecting abnormalities.
  • 2-dimensional brain ultrasound shear wave elastography (SWE) offers a non-invasive method to assess tissue stiffness.

Purpose of the Study:

  • To demonstrate the feasibility of 2-dimensional brain ultrasound shear wave elastography (SWE) in term neonates.
  • To define the average elasticity values of gray matter (thalamus) and white matter (corona radiata) in healthy term neonates.

Main Methods:

  • Prospective observational study of 55 healthy term neonates (37-40 weeks gestation) between 2-3 postnatal days.
  • Cerebral SWE examination using a multifrequency 4-9 MHz transducer, focusing on bilateral sagittal planes of the thalamus and corona radiata.
Keywords:
acoustic radiation force impulse imagingbrainelastographyneonateultrasound

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  • Quantitative SWE method with 5-15 measurements averaged from the 5 most central nonoverlapping areas in each region.

    • Main Results:

    • Successful cerebral SWE evaluation in all 55 neonates.
    • Statistically significant difference in mean velocity (elasticity) between the thalamus (1.17 m/s) and corona radiata (1.60 m/s) (P < .001).
    • No significant influence of laterality, gestational age, cephalic perimeter, sex, length, or delivery type on stiffness measurements.

    Conclusions:

    • 2-dimensional brain ultrasound SWE is a feasible technique for measuring neonatal brain elasticity.
    • Distinct elasticity values exist for the thalamus and corona radiata in healthy term neonates.
    • Establishing normal SWE ranges aids in comparative studies of neonatal brain pathology.