Related Experiment Video

Updated: Dec 10, 2025

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

542

Hypertension (Blood Pressure) and Lifetime Risk of Target Organ Damage

Daniel W Jones1, Donald C Clark2

  • 1Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. djones@umc.edu.

Current Hypertension Reports
|September 3, 2020
PubMed

Insights

Blood pressure, even below hypertension levels, poses long-term cardiovascular risks. Early intervention, potentially including medication for stage 1 hypertension, is crucial for preventing target organ damage.

Area of Science:

  • Cardiology
  • Public Health

Background:

  • Contemporary definitions of hypertension may underestimate cardiovascular disease risk.
  • Blood pressure's impact on target organ damage begins at lower levels.

Purpose of the Study:

  • To review the long-term relationship between blood pressure and target organ damage.
  • To emphasize that cardiovascular risk exists below current hypertension thresholds.

Main Methods:

  • Review of existing literature and clinical guidelines.
  • Analysis of data from major cardiovascular studies, including the CARDIA study.
  • Consideration of the 2017 ACC/AHA Blood Pressure Management Guidelines.

Main Results:

  • Cardiovascular disease risk is evident even with blood pressure levels below the defined hypertension stage 1 threshold (130/80 mmHg).
  • The CARDIA study showed significant cardiovascular risk over 20 years for individuals with stage 1 hypertension.
  • Recent guidelines redefined hypertension and treatment goals, emphasizing lifestyle therapy but potentially underestimating medication needs.

Conclusions:

  • Clinicians should consider medication for stage 1 hypertension if lifestyle modifications are insufficient.
  • A comprehensive understanding of blood pressure's lifelong impact is essential for preventing target organ damage.
  • Risk assessment for cardiovascular disease should account for blood pressure levels below traditional hypertension definitions.
Abstract

Keywords:
Blood pressureCardiovascular diseaseHypertensionRiskStage 1Young adult

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.0K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.2K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
319
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
530
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
414
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
547
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
227