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Updated: Dec 10, 2025

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
[Chikungunya]
1Service des maladies infectieuses et tropicales, CHU de Martinique, Fort-de-France, France ; université des Antilles, France.
Abstract:
Chikungunya. Chikungunya is a cosmopolitan arbovirosis transmitted by a mosquito of the genus Aedes. It is characterized by the possible persistence of musculoskeletal symptoms more than three months after infection. After inoculation by an infected mosquito and incubation for three days, the infection is symptomatic in 75-95% of cases. There are three stages. The acute stage is characterized by the sudden onset of high fever associated with incapacitating distal polyarthralgia. Atypical, sometimes severe, manifestations are possible: neurological, digestive, cardiac, hepatic, dermatological, hematological, pulmonary and renal. These atypical forms are most often observed at extreme ages and in people with chronic diseases. The post-acute stage (60-80% of cases, from the fourth week to the end of the third month) is characterized by persistent and polymorphic musculoskeletal manifestations. During the chronic stage (50% of cases from the fourth month onwards) two entities can be distinguished: chronic inflammatory rheumatism and musculoskeletal disorders. Management is symptomatic. It is based on a precise semiological analysis, attentive listening to the patient and a multidisciplinary approach.

