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Conducting polymer hydrogels for electrically responsive drug delivery.

Mahima Bansal1, Anusha Dravid1, Zaid Aqrawe2

  • 1School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 3, 2020
PubMed
Summary

Conducting polymer hydrogels offer tuneable, on-demand drug delivery. These advanced materials show promise for next-generation electrically responsive devices, despite current challenges in precise, long-term release.

Keywords:
Electrically tuneable drug deliveryInterpenetrating conducting polymer hydrogelsOn-demand drug deliveryStimuli responsive drug delivery

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Electrically responsive drug delivery enables localized and tunable drug release.
  • Conducting polymers and hydrogels are individually studied for drug delivery.
  • Hybrid conducting polymer hydrogels combine properties for enhanced drug delivery potential.

Purpose of the Study:

  • To review fabrication methods and properties of conducting polymer hydrogels for drug delivery.
  • To discuss drug loading and release mechanisms within these systems.
  • To present current applications and future directions for clinical translation.

Main Methods:

  • Literature review of conducting polymer hydrogels.
  • Analysis of material properties relevant to drug delivery.
  • Discussion of drug loading/release mechanisms and applications.

Main Results:

  • Conducting polymer hydrogels offer potential for extended and increased drug delivery.
  • Challenges remain in achieving accurate and long-term on-demand drug release.
  • These hybrid materials are promising for future electrically responsive drug delivery devices.

Conclusions:

  • Conducting polymer hydrogels are promising for next-generation electrically responsive drug delivery.
  • Further research is needed to overcome current challenges for clinical translation.
  • Successful development could lead to significant real-world therapeutic benefits.