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Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

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Stimuli-Responsive Rifampicin-Based Macromolecules.

Izabela Zaborniak¹, Angelika Macior², Paweł Chmielarz¹

¹Department of Physical Chemistry, Faculty of Chemistry, Rzeszow University of Technology, al. Powstańców Warszawy 6, 35-959 Rzeszów, Poland.

Materials (Basel, Switzerland)

|September 4, 2020

Summary

Researchers modified the antibiotic rifampicin using a novel polymerization technique to create smart polymer materials. These pH-responsive polymers can control the release of active substances like quercetin.

Keywords:

preparative electrolysis rifampicin-based ATRP initiator stimuli-responsive polymer materials

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Area of Science:

Polymer Chemistry
Materials Science
Drug Delivery

Background:

Stimuli-responsive polymers offer advanced functionalities for targeted applications.
Modifying existing drugs like rifampicin can lead to novel drug delivery systems.
Controlled polymerization techniques are crucial for designing polymers with specific properties.

Purpose of the Study:

To synthesize novel stimuli-responsive polymer materials by functionalizing rifampicin.
To develop a pH-sensitive polymer capable of controlled release of active substances.
To investigate the electrochemical and structural properties of the synthesized materials.

Main Methods:

Simplified electrochemically mediated atom transfer radical polymerization (seATRP) was employed.
Rifampicin was functionalized to create a macroinitiator.
Nuclear magnetic resonance (NMR), FT-IR, and UV-vis spectroscopy confirmed the initiator structure.
Cyclic voltammetry (CV) determined electrochemical catalytic rate constants.
Dynamic light scattering (DLS) analyzed pH-dependent polymer behavior.

Main Results:

Controlled synthesis of rifampicin-based polymers with narrow molecular weight distribution was achieved.
The synthesized polymers exhibited pH-responsive behavior.
Controlled release of quercetin was demonstrated in response to pH changes.
The electrochemical properties of the catalytic complexes were investigated.

Conclusions:

The study successfully developed novel pH-responsive polymer materials based on rifampicin.
The seATRP technique provides a controlled method for synthesizing functional polymers.
These smart materials show potential for controlled drug delivery applications.