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Updated: Dec 10, 2025

In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
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In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function

Published on: February 27, 2019

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Outcomes following immunotherapy re-challenge after immune-related adverse event: systematic review and meta-analysis

Robin Park1, Laercio Lopes1, Anwaar Saeed2

  • 1Department of Medicine, MetroWest Medical Center/Tufts University School of Medicine, Framingham, MA 01702, USA.

Immunotherapy
|September 4, 2020
PubMed

Background: Given the inconclusive evidence behind the safety and efficacy of immune checkpoint inhibitors re-challenge, herein, we have conducted a systematic review and meta-analysis to synthesize available data. Results/methodology: PubMed, Embase, Cochrane Database, and ASCO and ESMO were searched for studies published from conception to March 2020. Pooled incidence of recurrent immune-related adverse events (irAEs), objective response rates, and odds ratios for irAEs at initial versus re-treatment were calculated. Overall, 437 patients (ten studies) were included. Incidence of any grade, grade 3/4, and steroid-requiring recurrent irAEs were 47%, 13.2%, and 26% respectively. Objective response rate in previous non-responders was 12.5% (5.8-24.8%). Odds ratio for severe irAEs was 0.28 (0.11-0.72) and steroid-requiring irAEs 0.19 (0.06-0.56). Discussion/conclusion: This analysis suggests that immune checkpoint inhibitors re-challenge is safe and potentially efficacious.

Keywords:
anti-CTLA-1anti-PD-1anti-PD-L1immune checkpoint inhibitorimmune-related adverse eventsre-challenge

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