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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Breast Cancer in Older Adults.

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    |September 4, 2020
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    Summary

    Older women are disproportionately affected by breast cancer, but clinical trials often exclude them. This article reviews emerging evidence to guide personalized screening and management decisions for this population.

    Area of Science:

    • Oncology
    • Geriatric Medicine
    • Public Health

    Background:

    • Breast cancer predominantly affects older women, yet this demographic is underrepresented in clinical research.
    • Lack of evidence hinders informed decision-making for screening and treatment in elderly breast cancer patients.
    • Recent shifts in screening guidelines for older women necessitate updated clinical understanding.

    Purpose of the Study:

    • To synthesize current evidence on breast cancer presentation and progression in older women.
    • To support clinicians in making personalized screening and management recommendations for elderly patients.
    • To address the evidence gap in geriatric breast oncology.

    Main Methods:

    • Literature review of recent studies on breast cancer in older women.

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  • Analysis of clinical trial data and epidemiological reports.
  • Synthesis of evidence regarding screening mammography and treatment outcomes.

    • Main Results:

    • Emerging research highlights unique aspects of breast cancer in older populations.
    • Evidence is accumulating to inform age-specific screening and management strategies.
    • Personalized decision-making models are crucial for this demographic.

    Conclusions:

    • Addressing the underrepresentation of older women in breast cancer research is critical.
    • Clinicians need updated evidence to provide tailored care for elderly breast cancer patients.
    • Personalized screening and management improve outcomes for older women with breast cancer.