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Published on: May 30, 2025
Progress in the studies on the role of antisense long chain noncoding RNA in tumor development
Xiaowen Qiu1,2, Zhuo Lei3, Daofeng Lai4
1Department of Stomatology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, HaiKou 570208. qiuxiaowen@csu.edu.cn.
Abstract:
Antisense long chain noncoding RNA (lncRNA) is a new class of RNA molecules. In recent years, antisense lncRNA has been found to play an important role in many life activities including tumorigenesis and development. It has become a hot topic in biological research in recent years. Because of the special structure, many antisense lncRNAs have specific expression in tumor tissues and are closely related to the clinical data of the patients. Thus, antisense lncRNA is a potential tumor molecular marker. Further functional studies have shown that lncRNA can participate in gene regulation by means of miRNA sponge and RBP binding to play an important role in tumor cell cycle, apoptosis, angiogenesis, invasion and metastasis. More studies on the mechanisms of antisense lncRNA in cancer are of great theoretical significance in understanding the etiology and pathogenesis of malignant tumors and RNA language. At the same time, antisense lncRNA is a molecular marker or a potential target for the early diagnosis of malignant tumors. The antisense lncRNA may have a broad clinical application prospect in the evaluation of therapeutic effect, prognosis and even gene therapy.
Insights
Antisense long noncoding RNAs (lncRNAs) are crucial in cancer development and progression. These molecules show specific expression in tumors, making them potential biomarkers for early diagnosis and therapeutic targets.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Antisense long noncoding RNAs (lncRNAs) are a novel class of RNA molecules.
- lncRNAs play significant roles in biological processes, including tumorigenesis and development.
- Their specific expression in tumor tissues suggests potential as molecular markers.
Purpose of the Study:
- To explore the role and significance of antisense lncRNAs in cancer.
- To highlight their potential as diagnostic and therapeutic targets in oncology.
Main Methods:
- Review of current literature on antisense lncRNA function in cancer.
- Analysis of lncRNA mechanisms such as miRNA sponge and RBP binding.
- Correlation of lncRNA expression with clinical data.
Main Results:
- Antisense lncRNAs are implicated in regulating tumor cell cycle, apoptosis, angiogenesis, invasion, and metastasis.
- Specific expression patterns link lncRNAs to patient clinical data.
- lncRNAs function through miRNA sponge and RNA-binding protein (RBP) interactions.
Conclusions:
- Antisense lncRNAs are vital in understanding cancer etiology and pathogenesis.
- They hold promise as molecular markers for early cancer diagnosis.
- Potential clinical applications include prognosis evaluation and gene therapy.
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