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Related Experiment Video

Updated: Dec 10, 2025

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

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Effect of Paracentesis on Retinal Function Associated With Changes in Intraocular Pressure Caused by Intravitreal

Kazuma Kitsu¹, Kei Shinoda^1,2, Yoshinobu Mizuno¹

¹Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.

Translational Vision Science & Technology

|September 4, 2020

Summary

Anterior chamber paracentesis before anti-VEGF injections prevents increased intraocular pressure and minimizes retinal dysfunction. This procedure helps preserve retinal function by mitigating adverse electrophysiological changes.

Keywords:

anterior chamber paracentesis electroretinogram intraocular pressure ocular perfusion pressure

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Area of Science:

Ophthalmology
Retinal Physiology
Surgical Innovation

Background:

Intravitreal injections of anti-VEGF agents are common treatments.
Elevated intraocular pressure post-injection can damage retinal nerve fibers.

Purpose of the Study:

To evaluate the impact of anterior chamber paracentesis prior to anti-VEGF injections.
To assess the effects on electroretinograms (ERG) and intraocular pressure (IOP).

Main Methods:

Retrospective observational study of 25 patients.
Recorded IOP and ERG (a-wave, b-wave, PNR, OP) pre- and post-procedure.
Calculated ocular perfusion pressure.

Main Results:

Anterior chamber paracentesis significantly reduced IOP (6.8 ± 4.3 mm Hg) compared to baseline (24.1 ± 8.1 mm Hg) and post-injection (17.1 ± 9.6 mm Hg).
A significant decrease in b-wave amplitude was observed post-injection (P=0.02).
No significant changes in ERG latencies or other components were noted.

Conclusions:

Anterior chamber paracentesis effectively prevents IOP spikes after intravitreal injections.
This procedure mitigates electrophysiological retinal dysfunction, preserving retinal function.