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Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
Brain amyloid and Alzheimer disease
H V Vinters1, B L Miller, W M Pardridge
1Department of Medicine, UCLA School of Medicine.
Annals of Internal Medicine
|July 1, 1988
Summary
Alzheimer disease, a common dementia, involves brain lesions sharing amyloid properties. Understanding amyloid
Area of Science:
- Neuropathology
- Neurodegenerative Diseases
- Biochemistry
Background:
- Alzheimer disease is the most frequent cause of dementia.
- Key features include microscopic brain lesions.
- Amyloid is a significant component of these lesions.
Purpose of the Study:
- To present clinicopathologic features of Alzheimer disease.
- To discuss the role of brain amyloid in pathogenesis.
- To explore potential treatments based on amyloid biochemistry.
Main Methods:
- Review of clinicopathologic features in Alzheimer disease.
- Biochemical and staining property analysis of brain lesions.
- Discussion of etiological theories and treatment strategies.
Main Results:
- Microscopic brain lesions in Alzheimer disease exhibit amyloid staining properties.
- Senile plaque cores and amyloid angiopathy are biochemically identical amyloid.
- Amyloid's role in pathogenesis is linked to dementia theories.
Conclusions:
- Brain amyloid is central to Alzheimer disease pathology.
- Understanding amyloid processing may lead to effective treatments.
- Further research into amyloid biochemistry is crucial for Alzheimer disease management.
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