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Updated: Dec 10, 2025

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[Laboratory testing in intensive care medicine].

S Petros1,2, L Weidhase3

  • 1Interdisziplinäre Internistische Intensivmedizin, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland. sirak.petros@medizin.uni-leipzig.de.

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Summary

This study explores the use of laboratory tests in intensive care medicine. It finds that about half of these tests may be unnecessary. The authors suggest that test ordering is often driven by uncertainty and concern about missing a diagnosis. Standardized test profiles may not always align with clinical needs. Normal reference ranges may not apply to critically ill patients, leading to confusion between physiological stress and pathology. Untargeted testing can lead to iatrogenic anemia and increased costs. The study recommends that tests should be chosen based on specific clinical questions. Point-of-care tests are consistently used to assess homeostasis and critical care scores. The authors propose that targeted testing can improve patient outcomes and reduce costs.

Keywords:
Critical illnessDecision-makingDiagnosisEmergency medicineLaboratory diagnosisintensive care diagnosticslaboratory test overutilizationcritical care medicinediagnostic testing practices

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Area of Science:

  • Intensive care medicine
  • Clinical diagnostics
  • Laboratory medicine

Background:

Clinical diagnostics rely heavily on patient history and physical examination. Despite this, laboratory testing remains a common practice in critical care settings. However, a significant proportion of these tests may be unnecessary. The lack of detailed patient history can lead to broad, non-specific testing. Concerns about missing a pathology may also drive overutilization. Standardized laboratory profiles are often used to streamline testing. These profiles may not align with a specific diagnosis. Normal reference ranges are based on healthy populations and may not apply to critically ill patients. This mismatch can lead to confusion between physiological stress and pathological changes.

Purpose Of The Study:

The purpose of the study is to examine the role of laboratory testing in intensive care medicine. It aims to highlight the frequency of overutilization in this setting. The study seeks to identify reasons for excessive testing during initial patient admission. It also explores how diagnostic uncertainty influences test ordering. The goal is to assess whether current testing practices align with clinical needs. The study investigates the impact of untargeted testing on patient outcomes. It also aims to evaluate the use of point-of-care tests in critical care. The ultimate aim is to promote more judicious use of laboratory resources.

Main Methods:

The study reviews existing literature on diagnostic practices in intensive care units. It analyzes patterns of laboratory test ordering during patient admission. It examines the rationale behind the use of standardized test profiles. The study assesses how patient history influences test selection. It evaluates the impact of physiological stress on laboratory values. The study compares normal reference ranges with those observed in critically ill patients. It considers the role of acute injury and treatment in altering test results. The study emphasizes the need for test selection based on specific clinical questions.

Main Results:

Approximately half of all laboratory tests ordered during initial admission may be unnecessary. Standardized test profiles are frequently used despite limited clinical relevance. Patient history is often insufficient to guide targeted testing. Normal reference ranges may not reflect changes in critically ill patients. Untargeted testing can lead to iatrogenic anemia and increased costs. Test results may be overlooked or lead to further unnecessary procedures. Point-of-care tests are consistently required for critical care assessments. These include blood gas analysis and lactate measurements.

Conclusions:

The authors suggest that overutilization of laboratory tests is common in critical care settings. They propose that test selection should be guided by specific clinical questions. Standardized test profiles may not always align with diagnostic needs. The study highlights the importance of distinguishing between physiological and pathological changes. It emphasizes the need for careful interpretation of test results in critically ill patients. The authors suggest that point-of-care tests are essential for assessing homeostasis. They recommend avoiding unnecessary diagnostic steps to prevent iatrogenic harm. The study concludes that targeted testing can reduce costs and improve patient outcomes.

The authors suggest that untargeted tests may be overused due to diagnostic uncertainty and concern about missing pathology. These tests often lack a specific clinical question to guide their use.

Point-of-care tests are uniformly required in critical care to assess homeostasis and calculate critical care scores. These include blood gas analysis and lactate measurements.

Normal ranges are based on data from healthy subjects. The authors suggest that these do not account for physiological stress in critically ill patients, leading to confusion between adaptation and pathology.

The authors propose that untargeted testing may lead to iatrogenic anemia and increased costs. It may also result in unnecessary diagnostic steps and unjustified treatment.

The authors suggest that patient history may be insufficient to guide targeted testing. This may lead to overutilization of laboratory tests during initial admission.

The authors propose that every laboratory test should be chosen based on a specific clinical question. They suggest avoiding untargeted testing to reduce costs and iatrogenic harm.