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Oxidant and antioxidant balance in children with bacteremia

Kubra Aykac1, Yasemin Ozsurekci2, Sevgen Tanir Basaranoglu1

  • 1Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.

Minerva Pediatrics
|September 4, 2020
PubMed

Insights

Oxidative stress markers like total oxidant status (TOS), ischemia-modified albumin (IMA), myeloperoxidase (MPO), and plasma thiols are altered in children with bloodstream infections (BSI). These markers show potential for diagnosing bacteremia in pediatric patients.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Infectious Diseases

Background:

  • A critical balance exists between oxidant and antioxidant defense mechanisms in the body.
  • Disruptions in this balance are implicated in various pathological conditions, including infections.

Purpose of the Study:

  • To investigate the role of the oxidant-antioxidant balance in children diagnosed with bloodstream infections (BSI).
  • To identify potential biomarkers for the diagnosis of bacteremia in pediatric patients.

Main Methods:

  • Prospective analysis of serum samples from children with BSI and healthy controls.
  • Measurement of total antioxidant status (TAS), total oxidant status (TOS), albumin, plasma thiol, disulphide, catalase (CAT), myeloperoxidase (MPO), ischemia-modified albumin (IMA), ferroxidase, and arylesterase (ARES) activity.
  • Comparison of biochemical parameters between the patient group (n=50) and the control group (n=63).

Main Results:

  • Children with bacteremia exhibited significantly higher median TOS levels compared to healthy controls.
  • Mean serum IMA levels were significantly elevated in patients with bacteremia.
  • Significantly lower native thiol, total thiol, and disulphide levels were observed in the patient group.
  • Myeloperoxidase (MPO) levels were significantly higher in children with bacteremia.

Conclusions:

  • Total oxidant status (TOS), ischemia-modified albumin (IMA), myeloperoxidase (MPO), and plasma thiols are promising biomarkers for the accurate diagnosis of bacteremia in children.
  • These oxidative stress markers may aid in the early detection and management of bloodstream infections in pediatric populations.
Abstract

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