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Updated: Dec 10, 2025
Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
Published on: June 8, 2017
Comprehensive evaluation of risk factors for neonatal hearing loss in a large Brazilian cohort
Adriana R T Anastasio1, Aparecida Y Yamamoto2, Eduardo T Massuda3
1Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil. anastasi@fmrp.usp.br.
Objectives:
To determine the incidence and risk factors of hearing loss (HL) in Brazilian neonates.
Study Design:
11,900 neonates were screened for hearing and congenital CMV (cCMV). Low and high-risk babies who did not pass their hearing screening and infants with cCMV were scheduled for a diagnostic audiologic evaluation.
Results:
The incidence of HL was 2 per 1000 live-born infants (95% CI: 1-3). HL was higher in high-risk neonates than in low risk babies (18.6 vs. 0.3/1000 live births, respectively). Among infants exposed to isolated risk factors, association of HL with craniofacial abnormalities/syndromes (RR = 24.47; 95% CI: 5.9-100.9) and cCMV (RR = 9.54; 95% CI: 3.3-27.7) were observed. HL was 20 to 100-fold more likely in neonates exposed to ototoxic drugs in combination with cCMV or craniofacial/congenital anomalies.
Conclusions:
Strategies for the prevention of cCMV and exposure to ototoxic drugs may decrease the incidence of HL in this population.
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