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Somatosensation01:33

Somatosensation

42.6K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

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The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
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Association Areas of the Cortex01:21

Association Areas of the Cortex

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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
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Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

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The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
6.3K
Lateralization01:28

Lateralization

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Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
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Olfaction01:25

Olfaction

47.6K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Related Experiment Video

Updated: Dec 10, 2025

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
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Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

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Value-guided remapping of sensory cortex by lateral orbitofrontal cortex.

Abhishek Banerjee1,2, Giuseppe Parente3, Jasper Teutsch3,4

  • 1Laboratory of Neural Circuit Dynamics, Brain Research Institute, University of Zurich, Zurich, Switzerland. abhi.banerjee@newcastle.ac.uk.

Nature
|September 5, 2020
PubMed
Summary

Flexible decision-making relies on the orbitofrontal cortex (OFC). This study shows OFC signals value prediction errors to the somatosensory cortex (S1), enabling adaptive behavior and learning.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Decision Science

Background:

  • Flexible decision-making is crucial for adaptive behavior.
  • The frontal cortex, particularly the orbitofrontal cortex (OFC), is vital for this process in mammals.
  • Understanding how the OFC encodes decision variables and guides sensory areas remains a key challenge.

Purpose of the Study:

  • To investigate the dynamic interaction between the lateral OFC and the primary somatosensory cortex (S1) during adaptive decision-making.
  • To elucidate the neural mechanisms by which the OFC instructs sensory areas to guide behavior.
  • To explore the role of OFC-S1 communication in value-based learning and behavioral flexibility.

Main Methods:

  • Developed a reversal learning task for head-fixed mice.
  • Utilized two-photon calcium imaging to monitor lateral OFC neural activity.
  • Investigated neural activity longitudinally across different behavioral phases, including rule switching.

Main Results:

  • S1 neural activity reflected initial task learning, while lateral OFC neurons showed salient responses to rule switches.
  • Identified direct long-range projections from lateral OFC to S1, transmitting value prediction error signals.
  • Demonstrated that top-down OFC feedback functionally remapped S1 responses, updating sensory representations based on reward history.

Conclusions:

  • The dynamic interaction between the lateral OFC and S1 implements history-dependent, error-based value prediction computations.
  • Top-down OFC feedback is essential for plasticity in S1, crucial for flexible decision-making.
  • This neural circuit provides the plasticity necessary for adapting behavior based on changing environmental contingencies.