Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Requirements for Human Life01:26

Requirements for Human Life

12.2K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
12.2K
Persuasion Strategies01:52

Persuasion Strategies

42.8K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
42.8K
Ethical Standards II01:23

Ethical Standards II

1.1K
Ethical standards are the backbone of nursing practice, guiding nurses as they interact with patients, families, and colleagues. These standards are crucial for providing safe, empathetic care centered on the patient's needs.
Nurses are entrusted with upholding various ethical principles and standards. Nurses forge solid therapeutic relationships using trust, empathy, autonomy, confidentiality, and professional competence.
Confidentiality is crucial, embodying respect for individual privacy...
1.1K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

693
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
693
Ethical Standards I01:25

Ethical Standards I

1.3K
The American Nurses Association (ANA) created and implemented the first nationally accepted Code of Ethics for Nurses with Interpretive Statements. The Code of Ethics is a living document regularly updated by the ANA and establishes an ethical standard that is non-negotiable for nurses in all roles and settings.
The Code of Ethics provisions outline the nurse's duty to the patient, the healthcare team, the profession, and society. The Code's fundamental principles include advocacy,...
1.3K
Birth Control Methods01:22

Birth Control Methods

5.6K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Collision metastasis of lung adenocarcinoma and melanoma presenting as a fungating axillary mass.

JAAD case reports·2026
Same author

Correction: Artificial womb technology; a scoping review of ethical considerations.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Exfoliative Erythroderma Revealing Primary Central Nervous System Diffuse Large B-Cell Lymphoma.

Cureus·2026
Same author

Artificial womb technology; a scoping review of ethical considerations.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Treatment Decision-Making Roles and Preferences Among Adolescents and Young Adults With Cancer.

Pediatric blood & cancer·2026
Same author

A Review of The Efficacy of Complementary and Alternative Medicines in Managing Dermatologic Infectious Diseases.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Severe Nail Psoriasis and Early Psoriatic Arthritis: Illustrative Cases Confirming That Severity of Disease Is Not Solely Dependent on the Extent of Body Surface Area.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Pipeline of Devices and Aesthetics: What Is Left?

The Journal of clinical and aesthetic dermatology·2026
Same journal

An Analysis of Thyrotropin Levels in Patients With Nonscarring Alopecia: A Single-Center Retrospective Comparative Study.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Exploring the Therapeutic Potential of Topical Honey in Atopic Dermatitis.

The Journal of clinical and aesthetic dermatology·2026
Same journal

Plant Exosome Injection: A New Boost for Postlaser Vascular Repair.

The Journal of clinical and aesthetic dermatology·2026
Same journal

The Treatment of Perioral (Periorificial) Dermatitis With Topical Roflumilast 0.3% Cream: An Illustrative Case Study With Rapid Onset and Prolonged Remission.

The Journal of clinical and aesthetic dermatology·2026
See all related articles

Related Experiment Video

Updated: Dec 10, 2025

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.8K

iPLEDGE Must Abstain from Abstinence.

Kami Lowery1,2,3, Theodore Rosen1,2,3, Janet Malek1,2,3

  • 1Ms. Lowery is with Baylor College of Medicine in Houston, Texas.

The Journal of Clinical and Aesthetic Dermatology
|September 5, 2020
PubMed
Summary
This summary is machine-generated.

The iPLEDGE program should remove abstinence as a contraceptive option for isotretinoin therapy. Requiring all patients to use proven contraception will reduce unintended pregnancies and improve patient care.

Keywords:
AccutaneFDAIsotretinoinREMSabstinenceacnebirth controlcontraceptioniPLEDGEpregnancyrisk managementteratogen

More Related Videos

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.5K
A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

11.5K

Related Experiment Videos

Last Updated: Dec 10, 2025

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.8K
The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

1.5K
A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats
10:35

A Procedure to Study the Effect of Prolonged Food Restriction on Heroin Seeking in Abstinent Rats

Published on: November 11, 2013

11.5K

Area of Science:

  • Dermatology
  • Public Health
  • Pharmacovigilance

Background:

  • Isotretinoin is highly effective for acne treatment but is a potent teratogen, necessitating strict distribution controls.
  • The current iPLEDGE program mandates two contraceptive forms or abstinence for pregnant-capable females to prevent fetal exposure.
  • Concerns exist regarding the efficacy and enforcement of abstinence as a sole contraceptive measure within the iPLEDGE program.

Purpose of the Study:

  • To advocate for revising the iPLEDGE program to eliminate abstinence as an acceptable contraceptive option.
  • To propose requiring all patients, irrespective of sexual activity, to use evidence-based contraception.
  • To highlight the potential benefits of an updated program (iPLEDGE-R) for public health and patient management.

Main Methods:

  • This manuscript presents a critical review and ethical argument for program revision.
  • It analyzes the efficacy of contraceptive methods and the implications of current iPLEDGE regulations.
  • The study proposes a standardized approach to contraception for all patients undergoing isotretinoin therapy.

Main Results:

  • Evidence suggests that abstinence alone is not a reliably effective contraceptive method.
  • Removing abstinence as an option could significantly reduce isotretinoin-associated pregnancies.
  • Standardizing contraception may enhance patient privacy and streamline care protocols.

Conclusions:

  • Revising the iPLEDGE program (iPLEDGE-R) to mandate proven contraception for all patients is ethically and pragmatically advantageous.
  • This change aims to minimize fetal exposure to isotretinoin and improve overall patient safety.
  • Further research is needed to refine strategies for achieving the program's public health objectives.