Related Experiment Videos
Release of prostacyclin from the dog saphenous vein by 5-hydroxytryptamine
1Institute of Interdisciplinary Research, School of Medicine, Université Libre de Bruxelles, Campus Erasme, Belgium.
European Journal of Pharmacology
|March 15, 1988
Abstract:
5-Hydroxytryptamine (5-HT) stimulated the release of prostacyclin (PGI2) from strips of the dog saphenous vein. This stimulation was maintained after mechanical removal of the endothelium. The effect of 5-HT was mimicked by alpha-methyl-5-hydroxytryptamine (alpha-CH3-5-HT) but not by 5-carboxamidotryptamine (5-CT) and it was inhibited by ritanserin. It is concluded that, in the dog saphenous vein, the stimulation of PGI2 release by 5-HT involves 5-HT2 receptors distinct from the '5-HT1-like' receptors that mediate contraction of the vessel.