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Related Experiment Video

Updated: Dec 10, 2025

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Multiple Xanthogranulomas in a Teenager.

Katelyn Urban1, Miesha Merati2, Lydia Parker2

  • 1Dermatology, Lake Erie College of Osteopathic Medicine, Greensburg, USA.

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|September 5, 2020
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Summary
This summary is machine-generated.

Juvenile xanthogranuloma (JXG) typically affects infants with single lesions. This case highlights multiple JXG lesions in a 17-year-old, suggesting varied presentations in older patients.

Keywords:
juvenile xanthogranulomamultiple xanthogranulomanevoxanthoendotheliomanon-langerhans cell histiocytosis

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Area of Science:

  • Dermatology
  • Histopathology
  • Pediatric Oncology

Background:

  • Juvenile xanthogranuloma (JXG) is a rare, non-Langerhans cell histiocytosis.
  • JXG commonly presents as a solitary cutaneous lesion in infancy.
  • Multiple JXG lesions are infrequently reported, particularly in older individuals.

Observation:

  • A 17-year-old female presented with multiple asymptomatic skin nodules and plaques.
  • Clinical presentation was atypical for the typical infantile JXG demographic.
  • Diagnostic confirmation relied on histopathologic examination.

Findings:

  • Histopathology revealed characteristic foamy histiocytes.
  • Touton giant cells were identified, confirming the diagnosis of xanthogranuloma.
  • The case represents a rare instance of multiple JXG in an adolescent.

Implications:

  • The clinical course and management of multiple JXG in older patients may differ from infantile cases.
  • This case expands the known spectrum of JXG presentation.
  • Further research is warranted to understand the natural history of atypical JXG presentations.