Recalcitrant Folliculitis Decalvans Treatment Outcomes With Biologics and Small Molecule Inhibitors

Area of Science:

• Dermatology
• Trichology
• Inflammatory Alopecia

Background:

• Folliculitis decalvans (FD) is a rare neutrophilic cicatricial alopecia.
• FD often proves resistant to conventional therapeutic approaches.
• Limited evidence exists for managing therapy-recalcitrant FD.

Purpose of the Study:

• To systematically review emerging treatments for recalcitrant Folliculitis decalvans.
• To analyze the efficacy of biologics, small molecule inhibitors, and other targeted therapies.

Main Methods:

• Systematic literature review.
• Analysis of studies investigating biologics, TNF inhibitors, JAK inhibitors, PDE4 inhibitors, and monoclonal antibodies.
• Focus on treatments for therapy-resistant Folliculitis decalvans.

Main Results:

• Identified various targeted therapies showing promise for recalcitrant FD.
• Summarized data on biologics, small molecule inhibitors, and immunomodulators.
• Highlighted the need for further research on optimal treatment strategies.

Conclusions:

• Novel therapeutic agents offer potential for managing treatment-resistant Folliculitis decalvans.
• Biologics and small molecule inhibitors represent promising avenues.
• Further investigation is warranted to establish definitive treatment guidelines for recalcitrant FD.