Related Experiment Video
Updated: Dec 10, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Always the Right Dose? Content Uniformity in Over 100 Different Formulations Tested
Eli Dijkers1, Hudson Polonini2, Anderson de Oliveira Ferreira2
1Fagron BV, Rotterdam, The Netherlands. eli.dijkers@fagron.com.
Compounded oral liquids using SyrSpend SF demonstrated superior content uniformity compared to extemporaneous capsules. This ready-to-use vehicle offers a reliable alternative for pediatric and elderly patients needing customized medication doses.
Area of Science:
- Pharmaceutical compounding
- Drug formulation
- Pediatric and geriatric pharmacotherapy
Background:
- Nonsterile compounded medications are essential for pediatric and elderly patients requiring dose adjustments or with swallowing difficulties.
- Pharmacists often choose between compounding capsules or oral liquids, with capsules sometimes perceived as preferable.
- However, studies reveal significant issues with weight variation and content uniformity in compounded capsules.
Purpose of the Study:
- To evaluate the content uniformity of oral liquid formulations prepared with SyrSpend SF.
- To compare the reliability of SyrSpend SF oral liquids against manually compounded extemporaneous capsules.
Main Methods:
- Analysis of 104 different formulations using the SyrSpend SF vehicle.
- Inclusion of 89 unique active pharmaceutical ingredients in the tested formulations.
- Testing of 6,414 individual samples for content uniformity.
Main Results:
- All 6,414 analyzed samples prepared with SyrSpend SF were within specified limits for content uniformity.
- This indicates high consistency across a wide range of formulations and active ingredients.
- No significant deviations from specifications were observed in the SyrSpend SF samples.
Conclusions:
- SyrSpend SF offers a reliable and consistent method for compounding oral liquid medications.
- It presents a potentially superior alternative to manually compounded capsules for ensuring content uniformity.
- This is particularly relevant for pediatric and elderly populations requiring precise dosing.
More Related Videos
13:54A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
Published on: August 18, 2023
11:27A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Related Concept Videos
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Drug Dissolution: Requirements and Profile Comparison
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Clinically Relevant Drug Product Specifications: Methods of Establishment
In Vitro Drug Dissolution: Compendial Testing Models I
Pharmaceutical Equivalents