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Cumulative Damage in Juvenile Idiopathic Arthritis: A Multicenter Study From the Pediatric Rheumatology Arab Group

Sulaiman M Al-Mayouf1, Soad Hashad2, Khulood Khawaja3

  • 1King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Arthritis Care & Research
|September 4, 2020
PubMed

Insights

Cumulative damage is common in Arab children with juvenile idiopathic arthritis (JIA). Family history and longer disease duration are associated with increased joint and extraarticular damage in JIA patients.

Area of Science:

  • Pediatric Rheumatology
  • Autoimmune Diseases
  • Clinical Immunology

Background:

  • Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition affecting children.
  • Understanding cumulative disease damage is crucial for managing JIA progression.
  • Limited data exists on JIA-related damage in Arab populations.

Purpose of the Study:

  • To assess cumulative articular and extraarticular damage in Arab children with JIA.
  • To identify factors associated with disease damage in this cohort.

Main Methods:

  • Multicenter, cross-sectional study across 7 Arab countries.
  • Included 702 JIA patients meeting ILAR criteria with >1 year disease duration.
  • Assessed damage using Juvenile Arthritis Damage Index (JADI-A and JADI-E).

Main Results:

  • 193 patients had joint damage (mean JADI-A 1.7±4.5), 156 had extraarticular damage (mean JADI-E 0.5±1.1).
  • Enthesitis-related arthritis showed highest JADI-A. JADI-A correlated with family history.
  • Both JADI-A and JADI-E correlated with longer disease duration.

Conclusions:

  • Cumulative damage is prevalent in Arab JIA patients.
  • Consanguinity and having a sibling with JIA were associated with greater damage.
  • Family history and disease duration are key factors in JIA damage.
Abstract

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