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A controlled study of dimethyl sulfoxide in interstitial cystitis
R Perez-Marrero1, L E Emerson, J T Feltis
1Department of Urology, Queen's University, Kingston, Ontario, Canada.
The Journal of Urology
|July 1, 1988
Summary
Dimethyl sulfoxide (DMSO) effectively treats interstitial cystitis, showing significant symptom improvement in 53% of patients compared to placebo. This study confirms DMSO
Area of Science:
- Urology
- Pharmacology
Background:
- Interstitial cystitis (IC) is a chronic bladder condition causing pain and discomfort.
- Current treatments for IC have limited efficacy and can cause side effects.
Purpose of the Study:
- To evaluate the effectiveness of intravesical dimethyl sulfoxide (DMSO) compared to placebo in patients with IC.
Main Methods:
- A controlled crossover trial involving 33 patients with IC.
- Patients received intravesical treatments of 50% DMSO or placebo (saline) every 2 weeks for 2 sessions.
- Response was assessed using urodynamic and symptomatic evaluations.
Main Results:
- Dimethyl sulfoxide showed superior subjective improvement (53% vs. 18% for placebo).
- Objective improvement was significantly higher in the DMSO group (93% vs. 35% for placebo).
- No significant side effects were reported with DMSO treatment.
Conclusions:
- Intravesical dimethyl sulfoxide is an effective treatment for interstitial cystitis.
- DMSO offers both subjective and objective improvements in IC patients.
- DMSO is a safe and well-tolerated therapeutic option for IC.