Functional capacity and left ventricular diastolic function in patients with type 2 diabetes
Marijana Tadic1, Jelena Suzic-Lazic2, Vladan Vukomanovic2
1Department of Cardiology, University Hospital "Dr. Dragisa Misovic - Dedinje", Heroja Milana Tepica 1, 11000, Belgrade, Serbia. marijana_tadic@hotmail.com.
Acta Diabetologica
|September 5, 2020
Summary
Left ventricular diastolic dysfunction (LVDD) significantly impairs cardiorespiratory fitness in type 2 diabetes mellitus (DM) patients. Managing glycemic control and LV mass is crucial for improving functional capacity.
Area of Science:
- Cardiology
- Endocrinology
- Exercise Physiology
Background:
- Type 2 diabetes mellitus (DM) is associated with cardiovascular complications.
- Left ventricular diastolic dysfunction (LVDD) is a common complication in DM patients.
- Cardiorespiratory fitness is a key indicator of cardiovascular health.
Purpose of the Study:
- To evaluate cardiorespiratory fitness in type 2 DM patients with varying degrees of LVDD.
- To identify relationships between LVDD, glycemic control, and cardiorespiratory parameters.
Main Methods:
- Study included 55 controls and 85 type 2 DM patients.
- Echocardiography assessed left ventricular (LV) structure and diastolic function.
- Cardiopulmonary exercise testing measured cardiorespiratory fitness (peak oxygen uptake, ventilation/carbon dioxide slope).
Main Results:
- DM patients, especially those with LVDD, exhibited higher LV hypertrophy and impaired diastolic function.
- Lower peak oxygen uptake and higher ventilation/carbon dioxide slope were observed in DM patients with LVDD.
- HbA1c, LV mass index, and mitral E/e' were independently associated with cardiorespiratory fitness parameters.
Conclusions:
- LVDD significantly reduces functional capacity in type 2 DM.
- Glycemic control, LV mass, and LVDD are independent predictors of cardiorespiratory fitness.
- Early detection of LVDD and intensive diabetes management may prevent target organ damage.
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