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The Interaction between Arachidonic Acid Metabolism and Homocysteine

Elisa Domi1, Malvina Hoxha1, Bianka Hoxha1

  • 1Department of Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana, Albania.

Endocrine, Metabolic & Immune Disorders Drug Targets
|September 5, 2020
PubMed

Insights

High homocysteine (HHcy) levels impact cardiovascular health and inflammation by altering arachidonic acid (AA) metabolism. Targeting HHcy in AA pathways may lead to new treatments and dietary interventions.

Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Metabolic Research

Background:

  • Hyperhomocysteinemia (HHcy) is a known risk factor for cardiovascular disease (CVD), inflammation, and neurological disorders.
  • Arachidonic acid (AA) metabolism plays a critical role in vascular homeostasis and inflammatory processes, with imbalances linked to CVD development.

Purpose of the Study:

  • To review the influence of homocysteine (Hcy) on arachidonic acid (AA) metabolism.
  • To explore potential therapeutic and dietary strategies targeting the interplay between Hcy and AA pathways.

Main Methods:

  • In silico literature searches were conducted using PubMed and Scopus.
  • Analysis of existing studies detailing the relationship between Hcy levels and AA metabolite synthesis and activity.

Main Results:

  • Altered Hcy levels affect AA release and metabolism.
  • Hcy influences the synthesis and activity of key AA metabolites, including prostaglandins (PGs), prostacyclin (PGI2), thromboxane (TXA), epoxyeicosatrienoic acids (EETs), and hydroxyeicosatetraenoic acids (HETEs).

Conclusions:

  • Modulating Hcy within AA pathways offers potential for developing novel therapeutic compounds with improved pharmacological benefits.
  • Understanding this interaction is valuable for dietitians in developing dietary strategies to enhance health.

Keywords:
Homocysteinearachidonic acidcardiovascular diseasesepoxyeicosatrienoic acidshomeostasis.hyperhomocysteinemia

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