Processing in Lateral Orbitofrontal Cortex Is Required to Estimate Subjective Preference during Initial, but Not
Matthew P H Gardner1, Davied Sanchez1, Jessica C Conroy1
1NIDA Intramural Research Program, Baltimore, MD 21224, USA.
Neuron
|September 5, 2020
Summary
The orbitofrontal cortex (OFC) is not essential for habitual choices. However, lateral OFC inactivation impaired economic decision-making when novel choices required integrating new information.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Behavioral Economics
Background:
- The orbitofrontal cortex (OFC) is implicated in economic decision-making.
- Inactivating the OFC does not affect well-practiced choices, suggesting habituation or policy-based decision-making may bypass OFC involvement.
Purpose of the Study:
- To investigate the role of the OFC in economic choices involving novel versus experienced offers.
- To test the hypothesis that well-practiced decisions are habit-based and do not require OFC, while novel decisions do.
Main Methods:
- Rats were trained to make choices between different pellet pairs.
- OFC subregions were inactivated during choices involving novel offers or novel pairs.
- Performance on novel choices was compared to choices between experienced offers.
Main Results:
- Control rats performed similarly on novel and experienced offers.
- Rats exhibited initial difficulty estimating subjective preferences for novel pairs.
- Lateral OFC inactivation exacerbated difficulties with novel pair choices.
Conclusions:
- Established economic choices rely on an underlying model or 'goods space'.
- The lateral OFC is crucial for economic behavior when new information must be integrated into an existing framework.
- OFC function in economic decision-making is context-dependent, particularly concerning novelty and information integration.
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