Premenstrual changes. Impaired hormonal homeostasis

Area of Science:

• Reproductive endocrinology
• Neuroendocrinology
• Women's health

Background:

• Premenstrual changes (PMCs) significantly impact women's health and quality of life.
• The underlying mechanisms driving PMCs remain largely unknown.
• Current treatments for PMCs lack definitive efficacy.

Purpose of the Study:

• To explore the potential pathophysiology of premenstrual changes (PMCs).
• To investigate the role of hormonal fluctuations in the luteal phase as a trigger for PMCs.
• To synthesize existing data for a cohesive understanding of PMC development.

Main Methods:

• Comprehensive review and evaluation of existing scientific literature on premenstrual changes.
• Analysis of data concerning hormonal and other substance level variations during the luteal phase.
• Systems biology approach to assess homeostatic regulation.

Main Results:

• Premenstrual changes (PMCs) are highly prevalent in the general population.
• Evidence suggests PMCs arise from transient homeostatic dysregulation across multiple physiological systems.
• Hormonal and biochemical fluctuations during the luteal phase are implicated as key triggers.

Conclusions:

• Premenstrual changes (PMCs) likely result from a temporary disruption in the body's internal balance.
• The differential timing and extent of hormonal shifts during the luteal phase are critical factors.
• Further research into these homeostatic mechanisms may pave the way for effective PMC treatments.