Protecting Connections from Synapse Elimination
Related Experiment Video
Updated: Dec 9, 2025

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
Published on: October 6, 2017
Gabrielle L Sell1, A Kimberley McAllister1
1Center for Neuroscience, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA.
Abstract:
A recent paper by Cong et al. provides exciting evidence that neurons contain proteins that protect synapses from complement-mediated synapse elimination. SRPX2 binds C1q and blocks microglial synapse engulfment. The findings point at SRPX2, and potentially other related sushi domain proteins, as possible targets for therapies for neurodevelopmental and neurodegenerative disorders.
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