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Updated: Dec 9, 2025

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Unbalanced Whole-Arm Translocation der(18;21)(q10;q10) in Hematological Malignancies
Manisha Brahmbhatt Sutariya1, Robin Dawn Clark1, Suzanne Wilson1
1Clinical Genetics Laboratory, Department of Clinical Laboratory, Loma Linda University Medical Center, Loma Linda, CA.
Objectives:
Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. However, combined der(18;21) (q10;q10) and gain of chromosome 21 is even rarer, with only three cases reported. The previous cases were with AML, AML-M2, and aCML diagnosis. We report the first case of Ph-like, B-lymphoblastic leukemia (B-ALL) with +21 and der(18;21)(q10;q10) which resulted in loss of 18p and a gain of 21q. We address tumorigenesis and morphological characteristics of hematological malignancies involving der(18;21)(q10;q10), along with a review of the literature.
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