Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Inflammatory Markers in Patients With Welders' Lung Disease
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Mevlüt Karataş1, Murat Büyükşekerci, Meşide Gündüzöz
1Department of Chest Diseases, Occupational and Environmental Diseases Hospital, Ankara, Turkey (Dr Karataş, Dr Öziş); Department of Pharmacology, Occupational and Environmental Diseases Hospital, Ankara, Turkey (Dr Büyükşekerci); Department of Family Medicine, Occupational and Environmental Diseases Hospital, Ankara, Turkey (Dr Gündüzöz); Department of Public Health, Occupational and Environmental Diseases Hospital, Ankara, Turkey (Dr Özakinci).
Objective:
To investigate neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with welders' lung disease (PWLD) and its relation with pulmonary function parameters.
Methods:
One hundred sixteen male PWLD and 118 healthy non-exposed individuals were recruited. Pulmonary function tests (PFTs), complete blood count, erythrocyte sedimentation rate (SED), c-reactive protein (CRP), NLR and PLR of both groups were retrospectively analyzed.
Results:
NLR, PLR, WBC, ESR, and CRP were significantly higher in PWLD compared to controls (all P < 0.001). All PFTs, except for FEV1/FVC, significantly decreased in PWLD compared to controls as. NLR correlated positively with ESR (r = 0.241 and P < 0.001).
Conclusion:
Our results show that NLR and PLR can be considered as new inflammatory markers in PWLD with their cheap, fast and easily measurable feature with routine blood count analysis.
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