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Clinical Research after COVID-19: Embracing a New Normal
Joel M Gelfand1, Brooke E Hefele2
1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
The Journal of Investigative Dermatology
|September 5, 2020
Summary
The COVID-19 pandemic disrupted dermatology clinical trials for psoriasis and other conditions. Researchers must adapt trial procedures to ensure patient safety and maintain scientific integrity amid the pandemic.
Area of Science:
- Dermatology
- Clinical Research
- Infectious Diseases
Background:
- The COVID-19 pandemic has significantly impacted global public health and daily life.
- Clinical trials in dermatology, specifically for conditions like psoriasis, atopic dermatitis, and hidradenitis, have faced numerous disruptions, including suspension and termination.
- The pandemic necessitates a re-evaluation of standard research protocols.
Purpose of the Study:
- To highlight the impact of the COVID-19 pandemic on dermatology clinical trials.
- To emphasize the need for clinical investigators to adapt research methodologies.
- To provide guidance on maintaining scientific rigor while mitigating transmission risks.
Main Methods:
- This study reviews the effects of the COVID-19 pandemic on ongoing and planned dermatology clinical trials.
- It discusses the challenges faced by researchers in maintaining trial continuity and patient safety.
- The abstract emphasizes the need for adaptive strategies in clinical research during a pandemic.
Main Results:
- Dermatology clinical trials for psoriasis, atopic dermatitis, and hidradenitis have been significantly disrupted.
- There is an urgent need for clinical investigators to adopt new procedures.
- Mitigating transmission of severe acute respiratory syndrome coronavirus 2 and conserving personal protective equipment are key challenges.
Conclusions:
- Clinical investigators must embrace a "new normal" to navigate the COVID-19 pandemic.
- Adapting research procedures is crucial for the continuation of dermatology clinical trials.
- Maintaining scientific rigor while ensuring safety and resource management is paramount.
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