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Updated: Dec 9, 2025

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Concomitant infection with COVID-19 and Mycoplasma pneumoniae
Allen Chung-Cheng Huang1, Chung-Guei Huang2, Cheng-Ta Yang3
1Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Insights
COVID-19 patients may have co-infections with other pathogens like Mycoplasma pneumoniae. Early screening for co-infections ensures comprehensive treatment and better patient outcomes for community-acquired pneumonia.
Area of Science:
- Infectious Diseases
- Pulmonology
- Virology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic.
- COVID-19 presents with symptoms like fever and cough, and radiographic findings such as ground-glass opacities.
- Distinguishing COVID-19 from community-acquired pneumonia (CAP) caused by atypical pathogens can be challenging.
Observation:
- Atypical pneumonia and COVID-19 share overlapping clinical and radiographic features.
- Co-infections with other pathogens in COVID-19 patients have been reported.
- This case highlights a patient with COVID-19 co-infected with Mycoplasma pneumoniae.
Findings:
- The patient diagnosed with COVID-19 also had a Mycoplasma pneumoniae co-infection.
- The patient recovered well following combination therapy targeting both infections.
- Clinical and radiographic presentations of COVID-19 can mimic or co-exist with other CAP pathogens.
Implications:
- Physicians should consider co-infections in COVID-19 patients presenting with pneumonia.
- Implementing routine screening for common co-infecting pathogens is crucial.
- Prompt and adequate treatment for co-infections can improve patient recovery and outcomes.
Abstract:
In late 2019, cases of atypical pneumonia caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were first reported in Wuhan, China. The disease was officially called coronavirus disease 2019 (COVID-19) and has been declared a pandemic disease by the World Health Organization (WHO). The clinical symptoms may include fever, cough, fatigue, headache, and diarrhea. The radiographic features comprise various presentations, including ground-glass opacities, tiny nodules, and consolidation. However, some atypical pathogens related to community-acquired pneumonia (CAP) may share similar presentations. They may be difficult to distinguish according to the clinical presentation and radiographic findings. Recently, there have been several reports reminding physicians to heed the possibility of co-infection with other pathogens in patients diagnosed with COVID-19. We report a COVID-19 patient co-infected with Mycoplasma pneumoniae who recovered well after combination therapy. We propose that all COVID-19 patients should undergo a meticulous screening routine to ensure that they receive adequate treatments.
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