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Defining and Predicting Early Recurrence after Resection for Gallbladder Cancer
Kota Sahara1,2, Diamantis I Tsilimigras2, Yutaro Kikuchi1,2
1Department of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Annals of Surgical Oncology
|September 6, 2020
Summary
A new Gallbladder Cancer Recurrence Risk (GBRR) score helps predict early recurrence after surgery. This online tool aids clinicians in optimizing patient surveillance and prognosis counseling.
Area of Science:
- Oncology
- Surgical Oncology
- Cancer Prognostics
Background:
- Early recurrence (ER) timing post-gallbladder cancer (GBC) resection lacks clear definition.
- Predicting ER is crucial for effective patient management after GBC surgery.
Purpose of the Study:
- To develop and validate a novel Gallbladder Cancer Recurrence Risk (GBRR) score.
- To predict early recurrence in patients undergoing GBC resection.
Main Methods:
- Utilized data from 309 patients who underwent GBC resection (2000-2018).
- Defined optimal ER cutoff at 12 months using a minimum p-value approach.
- Developed and externally validated a risk stratification model based on clinicopathological factors.
Main Results:
- 103 patients (33.3%) experienced recurrence at a median 15.1-month follow-up.
- T3/T4 disease and poor tumor differentiation were significant predictors of ER.
- The GBRR score stratified patients into low, intermediate, and high-risk groups for 12-month recurrence-free survival, validated externally.
Conclusions:
- A novel online calculator (GBRR score) predicts ER probability after GBC resection.
- This tool can optimize surveillance strategies and patient prognosis counseling.
