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Updated: Dec 9, 2025

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Obesity, COVID-19 and innate immunometabolism
Laura E Gleeson1,2, Helen M Roche3,4, Frederick J Sheedy5
1School of Medicine, Trinity College, Dublin, Republic of Ireland.
Abstract:
As COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as ‘meta-flammation’, dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention.
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