Related Experiment Video
Updated: Dec 9, 2025

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
Early Extubation in Enhanced Recovery from Cardiac Surgery
Ciana McCarthy1, Nick Fletcher2
1Guys and St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK.
Abstract:
Prolonged intubation and mechanical ventilation following cardiac surgery have been associated with increased hospital and intensive care unit length of stays; higher health care costs; and morbidity resulting from atelectasis, intrapulmonary shunting, and pneumonia. Early extubation was developed as a strategy in the 1990s to reduce the high-dose opiate regimes and long ventilator times. Early extubation is a key component of the enhanced recovery pathway following cardiac surgery and enables early mobilization and early return to a normal diet. The plan to extubate should start as soon as the patient is scheduled for cardiac surgery and continue throughout the perioperative period.
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