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Oral Granulomatous Disease.

Faizan Alawi1, Bridget E Shields2, Temitope Omolehinwa3

  • 1Department of Basic and Translational Sciences, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104, USA.

Dermatologic Clinics
|September 7, 2020
PubMed
Summary

Granulomatous diseases cause chronic inflammation, often presenting nonspecific oral symptoms. Identifying the specific cause of oral granulomatous inflammation can be difficult without clear triggers.

Keywords:
Crohn diseaseForeign body reactionGranulomatosis with polyangiitisInfectious diseaseOrofacial granulomatosisPeriorificial dermatitisSarcoidosis

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Area of Science:

  • Oral pathology
  • Immunology
  • Dermatology

Background:

  • Granulomatous diseases are chronic inflammatory conditions with diverse causes.
  • Oral manifestations can be nonspecific, complicating diagnosis.
  • Identifying the etiology of oral granulomatous inflammation is often challenging.

Purpose of the Study:

  • To review conditions causing granulomatous inflammation in oral soft tissues.
  • To aid clinicians in diagnosing oral granulomatous conditions.

Main Methods:

  • Literature review of granulomatous diseases affecting oral tissues.
  • Clinical presentation analysis of various oral granulomatous conditions.

Main Results:

  • Oral granulomatous inflammation can stem from infectious and noninfectious agents.
  • Clinical appearance is often nonspecific, mimicking other oral lesions.
  • Systemic conditions can manifest as oral granulomatous inflammation.

Conclusions:

  • A broad differential diagnosis is essential for oral granulomatous inflammation.
  • Recognizing patterns and considering systemic associations aids diagnosis.
  • Further investigation is often required to determine the underlying cause.