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Related Experiment Video

Updated: Dec 9, 2025

Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
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Feasibility of Axillary Lymph Node Localization and Excision Using Radar Reflector Localization.

James Sun1, Danielle A Henry2, Michael J Carr3

  • 1Department of Breast Oncology, Moffitt Cancer Center, Tampa, FL; Present affiliation: Department of Surgery, University Hospitals, Cleveland Medical Center, Cleveland, OH.

Clinical Breast Cancer
|September 7, 2020
PubMed
Summary

Radar reflector-localization (RRL)-guided targeted axillary dissection (TAD) after neoadjuvant chemotherapy (NAC) is safe and feasible for breast cancer patients. This technique ensures accurate assessment of the nodal basin and confirms removal of positive axillary nodes.

Keywords:
ACOSOG Z1071Neoadjuvant chemotherapySAVI scoutTADTargeted axillary dissection

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Neoadjuvant chemotherapy (NAC) is standard for clinically detected nodal metastases in breast cancer.
  • Sentinel lymph node biopsy (SLNB) is feasible post-NAC.
  • Targeted axillary dissection (TAD) improves SLNB accuracy by excising biopsy-proven positive nodes.

Purpose of the Study:

  • To evaluate the safety and feasibility of radar reflector-localization (RRL)-guided TAD in breast cancer patients.
  • To assess the effectiveness of RRL clips in marking positive lymph nodes for excision.
  • To analyze the outcomes of RRL-guided TAD following NAC.

Main Methods:

  • Retrospective review of 45 clinically node-positive female breast cancer patients treated with NAC and RRL-guided TAD.
  • Data collection on clinicopathologic features and treatment outcomes.
  • Descriptive statistical analysis of collected data.

Main Results:

  • All 45 patients received NAC, primary breast surgery, and TAD.
  • RRL clips were successfully retrieved in all cases without complications.
  • The RRL node was the sentinel lymph node in 80% of patients.
  • 24 of 25 positive nodes were identified by RRL node excision, demonstrating high accuracy.

Conclusions:

  • RRL-guided TAD is a safe and feasible technique for breast cancer patients undergoing NAC.
  • This method facilitates accurate nodal basin assessment and confirmation of positive node excision.
  • RRL-guided TAD enhances the management of axillary metastases after neoadjuvant therapy.