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Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Microfluidic Biomaterials.

Joe Tien1,2, Yoseph W Dance1

  • 1Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.

Advanced Healthcare Materials
|September 7, 2020
PubMed
Summary
This summary is machine-generated.

Microfluidic biomaterials, featuring perfusable networks, are advanced scaffolds for tissue engineering. Their unique design enables controlled transport, enhancing applications like engineered blood vessels and tissues.

Keywords:
collagenhydrogelsmicrophysiological systemsmicrovascular tissue engineeringperfusion

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Microfluidics

Background:

  • Microfluidic biomaterials, developed since 2005, offer perfusable scaffolds.
  • They enable solute transport via convection and diffusion.
  • Key fabrication methods include micromolding, photopatterning, and 3D printing.

Purpose of the Study:

  • To review the current state of microfluidic biomaterials.
  • To explore their applications in tissue engineering.
  • To identify future research directions.

Main Methods:

  • Review of existing literature on microfluidic biomaterial fabrication and applications.
  • Analysis of transport mechanisms (convection and diffusion).

Main Results:

  • Microfluidic biomaterials are versatile scaffolds for tissue engineering.
  • Applications include engineering of microvessels, tubes, and cell-laden tissues.
  • Fabrication techniques allow for tailored material properties.

Conclusions:

  • Microfluidic biomaterials represent a significant advancement in scaffold design.
  • Their perfusability is key to their success in various tissue engineering applications.
  • Further exploration of this material class holds promise for future innovations.