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Updated: Dec 9, 2025

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Roles of miRNA and lncRNA in triple-negative breast cancer

Juan Xu1, Kang-Jing Wu1, Qiao-Jun Jia1

  • 1College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Journal of Zhejiang University. Science. B
|September 7, 2020
PubMed

Insights

Triple-negative breast cancer (TNBC) research is crucial due to its malignancy. Non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are key players in TNBC progression and potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) is a highly aggressive subtype lacking targeted therapies.
  • Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are increasingly recognized for their roles in cancer development.

Purpose of the Study:

  • To review the involvement of miRNAs and lncRNAs in TNBC progression, diagnosis, and neoadjuvant chemotherapy.
  • To elucidate the regulatory mechanisms of lncRNAs in TNBC, particularly their interplay with miRNAs.

Main Methods:

  • Literature review summarizing current research on ncRNAs in TNBC.
  • Analysis of aberrant miRNA and lncRNA expression patterns in TNBC.
  • Description of lncRNA gene regulation mechanisms and miRNA-mediated post-transcriptional regulation.

Main Results:

  • Identified specific miRNAs and lncRNAs with significant roles in TNBC progression.
  • Detailed lncRNA regulatory functions in both nuclear and cytoplasmic compartments.
  • Highlighted the synergistic action of lncRNAs and miRNAs in post-transcriptional gene regulation in TNBC.

Conclusions:

  • miRNAs and lncRNAs are critical in TNBC pathogenesis and progression.
  • Targeting these ncRNAs offers promising avenues for early diagnosis and novel therapeutic strategies for TNBC.
  • Understanding lncRNA-miRNA interactions provides new insights into TNBC treatment.
Keywords:
Biomarker; Long non-coding RNA (lncRNA); MicroRNA; Regulation mechanism; Triple-negative breast cancer (TNBC)

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