Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic radiobiology.

E J Hall1, M Astor, J Bedford

  • 1Department of Radiation Oncology, Columbia University, New York, New York 10032.

American Journal of Clinical Oncology
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetics of GS-441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021-2024).

The Journal of small animal practice·2025
Same author

Whole-Blood Taurine Concentrations in Cats With Intestinal Disease.

Journal of veterinary internal medicine·2017
Same author

Comparison of 3 Handling Techniques for Endoscopically Obtained Gastric and Duodenal Biopsy Specimens: A Prospective Study in Dogs and Cats.

Journal of veterinary internal medicine·2016
Same author

Campylobacter Species and Neutrophilic Inflammatory Bowel Disease in Cats.

Journal of veterinary internal medicine·2016
Same author

Bacterial Cholangitis, Cholecystitis, or both in Dogs.

Journal of veterinary internal medicine·2016
Same author

Does the Murphy's eye perform its role?

Anaesthesia·2015

Understanding radiation

Area of Science:

  • Radiation biology
  • Molecular mechanisms of radiation effects
  • Cellular and molecular radiobiology

Background:

  • Experimental studies on radiation's biological effects began soon after x-ray discovery.
  • Despite extensive research, many aspects of radiation's biological impact remain unknown.
  • Current understanding is based on decades of research by leading scientists in radiation biology.

Purpose of the Study:

  • To elucidate the mechanisms underlying radiation's biological effects at cellular and molecular levels.
  • To support and enhance current radiotherapy practices through a deeper understanding of radiation's impact.
  • To identify factors influencing radiosensitivity and radioresistance.

Main Methods:

  • Investigating DNA damage as a mechanism for cell injury and its role in lethality, transformation, and mutagenesis.

Related Experiment Videos

  • Studying cell lethality in vitro to identify repair mechanisms (sublethal, potentially lethal) and dose-rate effects.
  • Utilizing genetically deficient cell lines and molecular biology techniques to study DNA repair and gene regulation.

    • Main Results:

    • Identification of sublethal and potentially lethal DNA repair mechanisms and the dose-rate effect.
    • Established DNA damage as a key factor in cell injury, lethality, transformation, and mutagenesis.
    • Developed in vitro assays for mutagenesis and oncogenic transformation.

    Conclusions:

    • DNA damage and repair are critical determinants of radiation's biological effects.
    • Understanding radiosensitivity/radioresistance factors is crucial for future research and improved radiotherapy.
    • Further research is needed on low-dose effects, oncogene activation, and human cell-based assays.