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Recent developments in PARP14 research.

Amanda L Tauber1, Stephan M Levonis1, Stephanie S Schweiker1

  • 1Faculty of Health Sciences & Medicine, Bond University, Gold Coast 4229, Queensland, Australia.

Future Medicinal Chemistry
|September 7, 2020
PubMed
Summary
This summary is machine-generated.

This review highlights recent advances in poly(ADP-ribose) polymerase 14 (PARP14) research, focusing on its functions in viral replication, cancer, and inflammation. It also covers progress in designing PARP14 inhibitors, particularly targeting the macrodomain.

Keywords:
ARTD8PARPPARP14assay developmentcancerdrug developmentinflammationinhibitormacrodomainviral

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Poly(ADP-ribose) polymerases (PARPs) are crucial enzymes involved in DNA repair and cellular signaling.
  • PARP14, a member of the PARP superfamily, has emerged as a significant player in various biological processes.
  • Understanding PARP14's diverse roles is essential for therapeutic development.

Purpose of the Study:

  • To provide a comprehensive overview of key advancements in PARP14 research between late 2017 and early 2020.
  • To elucidate the expanding functional roles of PARP14, including its involvement in viral replication.
  • To summarize progress in the design of PARP14 inhibitors and related poly(ADP-ribose) polymerase (PARP) developments.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Analysis of studies investigating PARP14's molecular mechanisms and biological functions.
  • Evaluation of current strategies for developing selective PARP14 inhibitors.

Main Results:

  • PARP14 exhibits an emerging role in viral replication, alongside its established functions in cancer and inflammation.
  • Significant progress has been made in understanding PARP14's enzymatic activity and protein interactions.
  • The macrodomain of PARP14 has gained attention as a potential target for inhibitor design.

Conclusions:

  • PARP14 is a versatile enzyme with implications in infectious diseases, oncology, and inflammatory conditions.
  • Continued research into PARP14's functions and inhibitor development is crucial.
  • This review serves as an update to guide the development of selective PARP14-targeting therapeutics.