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The potential association between PARP14 and SARS-CoV-2 infection (COVID-19)

Amanda L Tauber1, Stephanie S Schweiker1, Stephan M Levonis1

  • 1Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Queensland 4229, Australia.

Future Medicinal Chemistry
|January 20, 2021
PubMed

Insights

Poly(ADP-ribose) polymerase 14 (PARP14) plays a key role in controlling the interferon response to SARS-CoV-2 infection. Its interaction with the virus suggests a complex relationship influencing the host immune response.

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • Poly(ADP-ribose) polymerase member 14 (PARP14) is implicated in viral infections.
  • The host immunopathological response to SARS-CoV-2 is not fully understood.
  • Understanding PARP14's role may elucidate SARS-CoV-2 pathogenesis.

Purpose of the Study:

  • To explore the potential mechanisms of PARP14 in SARS-CoV-2 infection.
  • To investigate PARP14's role in the host immune response to SARS-CoV-2.
  • To determine if PARP14 acts in a pro- or anti-viral manner.

Main Methods:

  • Literature review and theoretical analysis of PARP14 function in viral infections.
  • Examination of PARP14's involvement in interferon signaling pathways.
  • Analysis of potential interactions between SARS-CoV-2 proteins and PARP14.

Main Results:

  • PARP14 is crucial for regulating the interferon response during SARS-CoV-2 infection.
  • PARP14 may help balance pro-inflammatory cytokines implicated in cytokine storms.
  • The SARS-CoV-2 macrodomain can inhibit PARP14's antiviral activity.

Conclusions:

  • PARP14 is a significant factor in the host's immune response to SARS-CoV-2.
  • PARP14's function in SARS-CoV-2 infection is complex, potentially acting both for and against the virus.
  • Further experimental research is necessary to fully define PARP14's role and therapeutic potential.
Keywords:
ARTD8COVID-19PARP14SARS-CoV-2coronavirusimmunityviral

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