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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Sequential drug release via chemical diffusion and physical barriers enabled by hollow multishelled structures
Decai Zhao1,2, Nailiang Yang1,2, Yan Wei3
1State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Beiertiao, Zhongguancun, 100190, Beijing, PR China.
Nature Communications
|September 8, 2020
Summary
Hollow multishelled structures (HoMSs) demonstrate a unique, cell-like design for controlled drug delivery. These structures offer extended antibacterial protection and smart release capabilities, inspired by biological systems.
Area of Science:
- Nanomaterials Science
- Drug Delivery Systems
- Biomimetic Engineering
Background:
- Hollow multishelled structures (HoMSs) mimic cellular architecture with isolated cavities and hierarchical pores.
- Understanding mass transport in HoMSs is crucial for developing advanced functional materials.
- Existing antimicrobial agents often lack sustained release and responsiveness.
Purpose of the Study:
- To investigate the drug release kinetics of methylisothiazolinone (MIT) loaded into HoMSs.
- To evaluate the antibacterial efficacy and duration of MIT-loaded HoMSs.
- To explore the potential of HoMSs as intelligent, stimulus-responsive drug delivery systems.
Main Methods:
- Synthesis and characterization of HoMSs.
- Loading of methylisothiazolinone (MIT) as a model antibacterial agent into HoMSs.
- In vitro release studies to analyze drug release profiles.
- Assessment of antibacterial activity in a bacteria-rich environment.
Main Results:
- A triple-stage release profile was observed: burst release, sustained release, and stimulus-responsive release.
- HoMSs provided an approximately 8-fold longer sterility period compared to pure MIT.
- The HoMS system exhibited a smart responsive release mechanism triggered by environmental changes.
Conclusions:
- HoMSs enable temporally and spatially ordered drug release driven by chemical diffusion and physical barriers.
- The biomimetic design of HoMSs offers a promising strategy for prolonged antimicrobial activity and intelligent drug delivery.
- This work provides a novel route for designing advanced intelligent nanomaterials for various applications.
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