New and developing diagnostic platforms for COVID-19: A systematic review

Area of Science:

• * Medical Diagnostics
• * Virology
• * Radiology

Background:

• * The emergence of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in late 2019 led to a global pandemic.
• * Coronavirus Disease 2019 (COVID-19) rapidly spread worldwide, causing millions of infections and thousands of deaths.
• * Current diagnostic standards include reverse transcription-polymerase chain reaction (RT-PCR) and computed tomography (CT) scanning.

Purpose of the Study:

• * To systematically review current diagnostic methods for COVID-19 detection.
• * To explore the future prospects of emerging diagnostic technologies for SARS-CoV-2.
• * To discuss the status of commercially available diagnostic kits.

Main Methods:

• * Conducted online literature searches on Google Scholar, PubMed, and other online resources.
• * Included studies published between 2017 and mid-2020.
• * Focused on laboratory examinations, radiographical analysis, and potential sensors for COVID-19 detection.

Main Results:

• * Identified potential applications of nucleic acid technology, diagnostic radiology, and in-vitro diagnostic kits for COVID-19 detection.
• * Summarized emerging diagnostic technologies currently undergoing clinical trials.
• * Acknowledged limitations associated with each diagnostic technology.

Conclusions:

• * Nucleic acid technology, radiology, and in-vitro kits are key for COVID-19 detection.
• * Further collaboration and funding are essential to accelerate clinical trials for new diagnostic tools.
• * Continued development is needed to overcome limitations of current and emerging diagnostic methods.