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Updated: Dec 9, 2025

Bovine Mammary Gland Biopsy Techniques
Published on: December 23, 2018
Copy number variation analysis reveals variants associated with milk production traits in dairy goats
Xiaolong Kang1, Mingxun Li2, Mei Liu3
1Animal Genomics and Improvement Laboratory, BARC, USDA-ARS, Beltsville, MD, USA; College of Agriculture, Ningxia University, Yinchuan, China.
Abstract:
Copy number variation (CNV) is a major type of genomic structural variation. We investigated their impacts on goat dairy traits using the CaprineSNP50 array. From 120 samples of five dairy goat breeds, we totally identified 42 CNVs ranging from 56,044 bp to 4,337,625 bp. We found significant associations between two CNVs (CNV5 and CNV25) and two milk production traits (mean of milk fat yield and mean of milk protein yield) after false discovery rate (FDR) correction (P < 0.05). CNV5 overlaps the ADAMTS20 gene, which is involved in the differentiation of mammary cell and plays a crucial role in lactogenic activity of bovine mammary epithelial cells. CNV25 overlaps with PAPPA2, which has been found to be associated with bovine reproduction and milk production traits. Our results revealed that CNVs overlapped with ADAMTS20 and PAPPA2 could be involved in goat dairy traits and function as candidate markers for further genetic selection.
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