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Serum levels and urinary excretion of beta-2-microglobulin in patients with urinary bladder carcinoma
1Department of Tumor Pathology, Karolinska Hospital, Stockholm, Sweden.
Abstract:
The levels of beta 2-microglobulin in urine and serum were determined in 34 patients with urinary bladder carcinoma. In 22 patients (64%) serum beta 2-microglobulin was elevated and in 11 patients (32%) urinary excretion of the protein was increased. It was also found that all but 1 patient with elevated serum beta 2-microglobulin or urinary beta 2-microglobulin had WHO grade-II or grade-III tumors. In contrast, all patients with grade-I tumors, except 1, displayed normal levels of urine and serum beta 2-microglobulin.
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