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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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COVID-19 and Kidney Injury
1Division of Kidney Diseases and Hypertension, Department of Medicine, Alpert Medical School of Brown University, Providence, RI.
Rhode Island Medical Journal (2013)
|September 9, 2020
Summary
Acute kidney injury (AKI) is a frequent complication of COVID-19, with multifactorial causes including sepsis and direct viral infection. Management is supportive, and AKI significantly increases mortality risk in critically ill patients.
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a recognized complication of coronavirus disease 2019 (COVID-19).
- Previous studies show varied epidemiology, management strategies, and outcomes for AKI in COVID-19 patients.
- The precise pathophysiology linking COVID-19 and AKI requires further elucidation.
Purpose of the Study:
- To summarize the current understanding of acute kidney injury (AKI) in the context of COVID-19.
- To review the multifactorial etiology, risk factors, and management of AKI in COVID-19 patients.
- To highlight the impact of AKI on mortality and identify areas for future research.
Main Methods:
- Literature review and synthesis of existing data on AKI in COVID-19.
- Analysis of etiological factors, including systemic inflammation, sepsis, and direct viral effects.
- Identification of key risk factors and current supportive management approaches.
Main Results:
- The etiology of AKI in COVID-19 is multifactorial, involving sepsis, inflammation, vascular injury, and potential direct SARS-CoV-2 kidney infection.
- Older age, pre-existing comorbidities, and respiratory failure are significant risk factors for AKI development.
- AKI in COVID-19 patients, particularly those critically ill, is associated with substantially increased in-hospital mortality.
Conclusions:
- Acute kidney injury is a common and serious complication of COVID-19.
- Supportive care is the current standard management for AKI in these patients.
- Further research is warranted to explore antiviral treatments and long-term renal outcomes in COVID-19 survivors with AKI.
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