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Molecular genetics of the MHC
1Human Immunogenetics Laboratory, Imperial Cancer Research Fund, London, U.K.
Immunology. Supplement
|January 1, 1988
Summary
The major histocompatibility complex (MHC) is well-mapped in humans and mice, revealing gene and protein details. Future research will link MHC polymorphism to human leukocyte antigen (HLA) function and disease.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Genetics
Background:
- The major histocompatibility complex (MHC) is extensively mapped in humans and mice.
- DNA cloning and sequencing have provided detailed knowledge of MHC gene expression and protein composition.
- The structural basis of MHC polymorphism is now understood.
Purpose of the Study:
- To investigate the relationship between polymorphic domains in MHC sequences and the function of human leukocyte antigen (HLA) molecules.
- To explore the connection between MHC polymorphism and diseases associated with the MHC.
Main Methods:
- DNA cloning and sequencing
- Analysis of gene expression
- Protein composition analysis
- Structural analysis of polymorphism
Main Results:
- Detailed mapping of the MHC in humans and mice.
- Comprehensive understanding of expressed MHC genes and encoded proteins.
- Elucidation of the structural basis for MHC polymorphism.
Conclusions:
- The detailed knowledge of MHC structure and polymorphism allows for functional and disease association studies.
- Further research can now focus on how specific MHC sequences influence HLA function and disease susceptibility.