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Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review
Roman Řemínek1, František Foret1
1Institute of Analytical Chemistry, Czech Academy of Sciences, Brno, Czech Republic.
Electrophoresis
|September 9, 2020
Summary
This review summarizes over 80 capillary electrophoresis methods for pharmaceutical quality control of small molecule drugs. It covers various separation modes and detection techniques for analyzing active ingredients and impurities.
Area of Science:
- Pharmaceutical Analysis
- Separation Science
- Analytical Chemistry
Background:
- Capillary electrophoresis (CE) is a powerful separation technique with significant potential in pharmaceutical analysis.
- Routine quality control of small molecule drugs requires efficient and reliable analytical methods.
Purpose of the Study:
- To review capillary electrophoresis methods published since 2015 for routine quality control of small molecule drugs.
- To provide a comprehensive summary of applied electroseparation modes and detection techniques.
- To discuss the practical applications and contributions to separation science.
Main Methods:
- Literature review of capillary electrophoretic methods published from 2015 onwards.
- Categorization of methods based on electroseparation modes: capillary zone electrophoresis (CZE), electrokinetic chromatography (EKC), and micellar, microemulsion, and liposome-electrokinetic chromatography (MEKC, MMELC, LEC).
- Subcategorization based on detection techniques: UV, capacitively coupled contactless conductivity detection (C4D), and mass spectrometry (MS).
Main Results:
- More than 80 CE methods suitable for pharmaceutical quality control were identified and summarized.
- Methods cover the analysis of active pharmaceutical ingredients (APIs), degradation products, and enantiomeric impurities.
- Key procedural parameters are presented in four concise tables for easy reference.
Conclusions:
- Capillary electrophoresis offers a versatile platform for the quality control of small molecule drugs.
- The reviewed methods demonstrate the broad applicability of CE in analyzing APIs and related substances.
- This review contributes to the understanding and practical application of CE in pharmaceutical analysis.
Keywords:
Capillary electrophoresisDrug degradationDrug impurityElectrokinetic chromatographyEnantioseparationMore Related Videos
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