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Related Concept Videos

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Related Experiment Video

Updated: Dec 9, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
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Bronchiectasis associated with electronic cigarette use: A case series.

Eric S Mull1, Richard Shell1,2, Brent Adler2,3

  • 1Division of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.

Pediatric Pulmonology
|September 9, 2020
PubMed
Summary
This summary is machine-generated.

Electronic cigarette use, particularly with tetrahydrocannabinol, may be linked to new cases of pediatric bronchiectasis (BE). This condition, a permanent lung airway dilation, is concerning for chronic respiratory health in children.

Keywords:
bronchiectasis and primary ciliary dyskinesiaenvironmental lung diseaseimaginglung pathologypulmonary function testing (PFT)

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Area of Science:

  • Pulmonology
  • Pediatric Respiratory Medicine
  • Toxicology

Background:

  • Bronchiectasis (BE) is irreversible airway dilation, often linked to cystic fibrosis (CF) in children.
  • Non-CF related BE is an emerging cause of pediatric respiratory morbidity.
  • Chronic inflammation and infection drive airway structural changes in BE.

Purpose of the Study:

  • To investigate potential environmental factors contributing to newly diagnosed pediatric bronchiectasis.
  • To analyze cases of pediatric BE unrelated to cystic fibrosis at our institution.

Main Methods:

  • Retrospective case review of pediatric patients diagnosed with BE.
  • Detailed analysis of clinical history, including substance use.
  • Correlation of radiologic findings with clinical presentation.

Main Results:

  • Three cases of newly diagnosed pediatric bronchiectasis were identified.
  • All three cases involved at least one year of electronic cigarette use.
  • Tetrahydrocannabinol (THC) use was noted in conjunction with e-cigarette use.
  • Radiologic findings included BE, ground glass opacities, and nodule formation.

Conclusions:

  • Electronic cigarette use, especially with THC, may be an inciting factor for pediatric bronchiectasis.
  • Further research is warranted to establish causality and understand the mechanisms.
  • This highlights a potential public health concern regarding vaping products in adolescents.